Hemoglobin Cagliari (beta 60 [E4] Val----Glu): a novel unstable thalassemic hemoglobinopathy

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Further observation of Hemoglobin Beograd (B121 Glu-Val) in Turkish population.

Hemoglobin Beograd (B121 Glu-Val) is a rarely reported hemoglobin variant. It was first reported in Turkey in 1984. This report is a further observation of this variant in a 22-years old Turkish man.

متن کامل

Another Rare Unstable Hemoglobinopathy: Hemoglobin Casper/Southampton Associated with Moyamoya Disease

A 9-year-old right-handed girl with a history of hemolytic anemia, status post-splenectomy, and previously identified right frontal encephalomalacia presented with a 1-month history of episodic right upper extremity weakness and ‘garbled’ speech. Her neurological examination was notable for episodes of nonfluent speech and dysarthria, some right-left confusion, and episodic distal right arm wea...

متن کامل

Hemoglobin Rush (beta 101 (g3) glutamine): a new unstable hemoglobin causing mild hemolytic anemia.

A mild hemolytic anemia in a 43-yr-old black likely explanation of the instability is the woman was attributed to the presence of an abpresence of an uncovered positive chargs in the normal hemoglobin (Hb Rush) which migrated central cavity where normally glutamic acid in cathodically to Hb A at pH 8.0. Its structural position 101 neutralizes arginine in position abnormality was found to be in ...

متن کامل

A novel silent posttranslational mechanism converts methionine to aspartate in hemoglobin Bristol (beta 67[E11] Val-Met->Asp).

The first reported case of congenital Heinz body hemolytic anemia was subsequently shown to be caused by an unstable hemoglobin, Hb Bristol [beta 67(E11) Val-Asp]. This has become one of the classic models of an unstable hemoglobin, the hydrophilic aspartate disrupting the hydrophobic heme pocket. We have restudied this original case, who remains clinically well after nearly 50 years of severe ...

متن کامل

Hemoglobin Warsaw ( Phefl * ’ ( CD 1 ) II ) Val ) , an Unstable Variant with Decreased Oxygen Affinity

In Hb Warsaw Val replaces the Phe normally present at the heme contact position ,842 (CDl). This variant is unstable, and it readily undergoes methemoglobin formation. In DEAE-cellulose chromatography, the variant hemoglobin co-eluted with Bb A; a partially heme-depleted fraction of the variant, representing 56% of the total hemoglobin, eluted separately and in pure form. The heme replete form ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Blood

سال: 1991

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v77.2.371.371